领域内唯一杰青,原浙大重点实验室主任全职加盟复旦大学!

2021-09-23 01:53:35 柳叶刀学术

杰青、原浙江大学医学中心副主任、浙江省医学分子影像重点实验室主任田梅已全职加盟复旦大学,任人类表型组研究院教授、博士生导师。

田梅目前是世界分子影像学会主席,也是首位担任该职位的中国学者,是“透明病理”概念的提出者,同时是国内临床核医学唯一的杰青获得者

田梅个人简介

田梅,国家杰出青年科学基金获得者、科技部“重点领域创新团队”负责人。

长期从事影像医学与核医学、分子影像的临床、教学和科研工作,先后在国内外获得临床医学学士、影像医学硕士、内科学博士。

曾在哈佛大学医学院Dana-Farber Cancer Institute/Brigham and Women医院工作,担任美国MD Anderson癌症中心助理教授。

近20年来,田梅针对人类重大疾病的诊治难题,通过构建分子影像新技术、新方法,提高疑难疾病的早期诊断效率和准确率。通过研发和利用特异性分子识别的影像示踪剂(分子影像探针)、PET/CT及PET/MRI多模式影像融合技术、以及人工智能(AI)辅助影像分析技术,显著提高癫痫、老年痴呆、恶性肿瘤等的精准诊治水平。

目前主持国家自然科学基金委杰出青年基金项目、国际重点合作A3项目、基础科学中心项目课题,发表SCI英文论文100多篇,主编全国统编教材1部、副主编2部,主编英文专著1部。

当选世界分子影像学会(WMIS)主席、中国认知科学学会分子影像分会理事长。长期应邀担任“美国核医学与分子影像学会”会刊《Journal of Nuclear Medicine》副主编;“欧洲核医学会”会刊《European Journal of Nuclear Medicine and Molecular Imaging》副主编;“日本核医学会”会刊《Annals of Nuclear Medicine》副主编;“英国核医学会”会刊《Nuclear Medicine Communications》编辑委员;“世界分子影像学会”会刊《Molecular Imaging Biology》亚洲地区负责人;《Oncology》编辑委员; 中国工程院院刊《Frontiers of Medicine》编辑委员;中国科协和美国科学促进会《Research》Associate Editor;英国柳叶刀《Lancet》编辑顾问。

研究方向

1. 表型组学、表型影像学、分子影像学;

2. 基于表型影像、分子影像的精准诊断与新型治疗方法(包括干细胞、T细胞治疗,靶向治疗等),多模式(PET / CT / MRI / 光学等)影像介导的精准诊治一体化基础研究与临床应用;

3. 基于分子影像的人类重大疾病(神经与精神疾病、心梗、恶性肿瘤等)临床诊断与治疗方案设计、疗效精准评估与预后监测;

4. 基于脑机融合、影像组学、大数据、人工智能等的新型分子影像的精准临床诊治。

获奖情况

1. 教育部科技进步一等奖

2. 中国产学研合作创新一等奖

3. 日内瓦国际发明展金奖

4. 中国青年科技奖、中国青年女科学家奖

5. 中国青年五四奖章、全国三八红旗手

6. 世界分子影像(WMIS)Fellow

近五年代表论文

Tian M*, He X, Jin C, He X, Wu S, Zhou R, Zhang X, Zhang K, Gu W, Wang J, Zhang H*. Transpathology: molecular imaging based pathology. Eur J Nucl Med Mol Imaging. 2021 Feb 13. doi: 10.1007/s00259-021-05234-1.

Gao Y, Wu S, Pan J, Zhang K, Li X, Xu Y, Jin C, He X, Shi J, Ma L, Wu F, Yao Y, Wang P , He Q, Lan F*, Zhang H*, Tian M*. CRISPR/Cas9-edited triple-fusion reporter gene imaging of dynamics and function of transplanted human urinary-induced pluripotent stem cell-derived cardiomyocytes. Eur J Nucl Med Mol Imaging. 2021; 48(3):708-720

Zhang Q, Liao Y, Wang X, Zhang T, Feng J, Deng J, Shi K, Chen L, Feng L, Ma M, Xue L, Hou H, Dou X, Yu C, Ren L, Ding Y, Chen Y, Wu S, Chen Z, Zhang H*, Zhuo C*,Tian M*. A Deep Learning Framework for 18F-FDG PET Imaging Diagnosis in Pediatric Patients with Temporal Lobe Epilepsy. Eur J Nucl Med Mol Imaging. 2021. doi: 10.1007/s00259-020-05108-y

Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J, Zhao M, Tu M, Li F, Zhang H, Tian M*, Ling D*. A Tauopathy-Homing and Autophagy-Activating Nanoassembly for Specific Clearance of Pathogenic Tau in Alzheimer's Disease. ACS Nano. 2021;15(3):5263-5275.

Cai X, Zhang K, Xie X, Zhu X, Feng J, Jin Z, Zhang H, Tian M*, Chen H*. Self-assembly hollow manganese Prussian white nanocapsules attenuate Tau-related neuropathology and cognitive decline. Biomaterials, 2020 Feb;231:119678.

Dong S, Zhao J, Zhang M, Shi Z, Deng J, Shi Y, Tian M, Zhuo C*. DeU-Net: Deformable U-Net for 3D Cardiac MRI Video Segmentation. MICCAI 2020: Medical Image Computing and Computer Assisted Intervention – MICCAI 2020 pp 98-107.

Du R, Zhu X, Wu S, Zhang X, He Y, Zhang K, He X, Wang X, Sun Y, Wang Q, Zhang H*, Tian M*. PET imaging of metabolic changes after neural stem cells and GABA progenitor cells transplantation in a rat model of temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2019;46(11):2392-2397.

Zhang K, Tu M, Gao W, Cai X*, Song F, Chen Z, Zhang Q, Wang J, Jin C, Shi J, Yang X, Zhu Y, Gu W, Hu B, Zheng Y*, Zhang H*, Tian M*. Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis. Nano Lett. 2019;19(5):2812-2823.

Chen Q, Du Y, Zhang K, Liang Z, Li J, Yu H, Ren R, Feng J, Jin Z, Li F, Sun J, Zhou M, He Q, Sun X, Zhang H, Tian M*, Ling D*. Tau-Targeted Multifunctional Nanocomposite for Combinational Therapy of Alzheimer's Disease. ACS Nano. 2018;12(2):1321-1338.

Brammer DW#, Gillespie PJ#, Tian M#, Young D#, Raveendran M, Williams LE, Gagea M, Benavides FJ, Perez CJ, Broaddus RR, Bernacky BJ, Barnhart KF, Alauddin MM, Bhutani MS, Gibbs RA, Sidman RL*, Pasqualini R, Arap W, Rogers J, Abee CR, Gelovani JG*. MLH1-rheMac hereditary nonpolyposis colorectal cancer syndrome in rhesus macaques. Proc Natl Acad Sci U S A. 2018;115(11):2806-2811.

Ding Y, Zhu Y, Jiang B, Zhou Y, Jin B, Hou H, Wu S, Zhu J, Wang ZI, Wong CH, Ding M, Zhang H, Wang S, Tian M*. 18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy. Eur J Nucl Med Mol Imaging. 2018;45(9):1567-1572.

Zhu Y, Feng J, Ji J, Hou H, Chen L, Wu S, Liu Q, Yao Q, Du P, Zhang K, Chen Q, Chen Z, Zhang H, Tian M*. Alteration of monoamine receptor activity and glucose metabolism in paediatric patients with anticonvulsant-induced cognitive impairment. J Nucl Med. 2017;58(9):1490-1497.

Zhu Y, Feng J, Wu S, Hou H, Ji J, Zhang K, Chen Q, Chen L, Cheng H, Gao L, Chen Z, Zhang H, Tian M*. Glucose Metabolic Profile by Visual Assessment Combined with Statistical Parametric Mapping Analysis in Pediatric Patients with Epilepsy. J Nucl Med. 2017;58(8):1293-1299.

Chen Q, Zhang Y, Hou H, Du F, Wu S, Chen L, Shen Y, Chao F, Chung JK, Zhang H, Tian M*. Neural correlates of the popular music phenomenon: evidence from functional MRI and PET imaging. Eur J Nucl Med Mol Imaging. 2017;44(6):1033-1041.

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